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Research Paper Volume 11, Issue 18 pp 7570—7586

Upregulation of miR-93 and inhibition of LIMK1 improve ventricular remodeling and alleviate cardiac dysfunction in rats with chronic heart failure by inhibiting RhoA/ROCK signaling pathway activation

Figure 3. BNP, cTnI, AngII and NE levels were reduced by up-regulation of miR-93 or downregulation of LIMK1. (A) Comparison of plasma BNP levels in each group of rats; (B) Comparison of plasma cTnI levels in each group; (C) Comparison of plasma AngII levels in each group; (D) Comparison of NE levels in plasma of each group; *P < 0.05 vs. the sham group; #P < 0.05 vs. the mimics-NC group; & P < 0.05 vs. the siRNA-NC group; $P < 0.05 vs. the miR-93 mimics + OE-NC group; N = 8, the data were showed as mean ± standard deviation; data analysis was performed by one-way ANOVA, and LSD-t method was used for pairwise comparison after ANOVA.