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Research Paper Volume 11, Issue 18 pp 7570—7586

Upregulation of miR-93 and inhibition of LIMK1 improve ventricular remodeling and alleviate cardiac dysfunction in rats with chronic heart failure by inhibiting RhoA/ROCK signaling pathway activation

Figure 4. TNF-α, IL-1β, IL-6 levels were inhibited by up-regulation of miR-93 or downregulation of LIMK1. (A) Comparison of TNF-α, IL-1β, IL-6 levels in plasma of each group rats; (B) Protein bands of TNF-α, IL-1β, IL-6 in myocardial tissue of each group; (C) The protein expression of TNF-α, IL-1β, and IL-6 in myocardial tissue of each group;*P < 0.05 vs. the sham group; #P < 0.05 vs. the mimics-NC group; & P < 0.05 vs. the siRNA-NC group; $ P < 0.05 vs. the miR-93 mimics + OE-NC group; N = 8, the data were showed as mean ± standard deviation; data analysis was performed by one-way ANOVA, and LSD-t method was used for pairwise comparison after ANOVA.