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Research Paper Volume 11, Issue 18 pp 7570—7586

Upregulation of miR-93 and inhibition of LIMK1 improve ventricular remodeling and alleviate cardiac dysfunction in rats with chronic heart failure by inhibiting RhoA/ROCK signaling pathway activation

Figure 8. Cleaved caspase-3 and Bax levels were inhibited and Bcl-2 level was promoted by up-regulation of miR-93 or downregulation of LIMK1. (A) TUNEL staining was used to observe the apoptosis of cardiomyocytes in each group (× 400, scale bar 25 μm); (B) Apoptosis index of cardiomyocytes in each group; (C) Protein bands of Cleaved caspase-3, Bax, and Bcl-2 protein in myocardial tissues of each group; (D) Protein expression of Cleaved caspase-3 in myocardial tissue of each group; (E) Protein expression of Bax in myocardial tissues of rats in each group; (F) Protein expression of Bcl-2 in myocardial tissues of each group; *P < 0.05 vs. the sham group; #P < 0.05 vs. the mimics-NC group; & P < 0.05 vs. the siRNA-NC group; $P < 0.05 vs. the miR-93 mimics + OE-NC group; N = 8, the data were showed as mean ± standard deviation; data analysis was performed by one-way ANOVA, and LSD-t method was used for pairwise comparison after ANOVA.