Research Paper Volume 11, Issue 18 pp 7587—7604

Attenuated activation of the unfolded protein response following exercise in skeletal muscle of older adults

Figure 1. Pathway analysis of the unfolded protein response mRNA transcripts at baseline. Baseline UPR genes transcripts are not different at baseline in young vs. older adults (A) The x-axis represents the log fold change, while y-axis represents the –log FDR-value for each gene. UPR genes are colored in blue. Dotted vertical lines represent the threshold for statistical significance (FDR < 0.05, −log [FDR value] > 1.303). Gene set enrichment analysis (GSEA) of 72 gene transcripts associated with the UPR reveals a trend towards upregulation of mRNA for the unfolded protein response in skeletal muscle under basal conditions (B) in the older compared to younger adults (FDR < 0.05 and an absolute log2 fold change R ≥ 0.5).