Research Paper Volume 11, Issue 18 pp 7639—7662

miR-125a-5p inhibits tumorigenesis in hepatocellular carcinoma

Figure 5. miR-125a-5p suppresses PTPN1 and MAP3K11 expression via the MAPK signaling pathway in HCC. (A) Western blots indicated that miR-125a-5p overexpression reduced, while miR-125a-5p knockdown increased, the expression of JNK1/2/3 and c-Jun in Bel-7404 and SK-Hep1 cells. (B and C) Western blots showed that PTPN1 and MAP3K11 knockdown decreased the expression of JNK1/2/3 and c-Jun in Bel-7404 and SK-Hep1 cells.