Research Paper Volume 11, Issue 18 pp 7639—7662

miR-125a-5p inhibits tumorigenesis in hepatocellular carcinoma

Figure 7. miR-125a-5p suppresses cell proliferation and induces apoptosis by targeting PTPN1 and MAP3K11 via the MAPK signaling pathway in vivo. (A and B) Representative images of mice and xenografted tissues. (C and D) Xenograft tissue volumes and weights were analyzed (n=5). Two- and One-way ANOVAs, mean ± SD. **P<0.01, ***P<0.001. (E) PTPN1 and MAP3K11 expression was higher in HCC tumor tissues than in normal liver tissues in the Human Protein Atlas database. (F) Brdu, Ki67, PTPN1, MAP3K11, JNK1/2/3, and c-Jun expression were detected via immunofluorescence in xenografted tissuesat 400× magnification.