Research Paper Volume 11, Issue 18 pp 7663—7677

Association between promoter DNA methylation and gene expression in the pathogenesis of ischemic stroke

Figure 5. PPI network construction and hub item identification. (A) PPI network of the selected DMGs. Edges stand for the interaction between two genes. The significant modules recognized in the PPI network by the molecular complex detection technique with a score of > 7.0. (B) Molecular-1 with MCODE = 12; (C) Molecular-2 with MCODE = 9.8; (D) Molecular-3 with MCODE = 7.6. A degree was utilized to explain the prominence of protein nodes in the network; dark colors show a high degree, and light colors present a low degree.