Expression of Concern
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This article is currently under investigation. We strongly recommend that this article is not cited until the investigation is completed.
Research Paper Volume 11, Issue 18 pp 7780—7795
Sulfated polysaccharide of Sepiella maindroni ink targets Akt and overcomes resistance to the FGFR inhibitor AZD4547 in bladder cancer
Figure 2. SIP-SII hampers proliferation and migration of bladder cancer cells in an Akt-dependent manner. (A) Cell viability (MTT) assay results for RT112 and JMSU1 cells treated with negative control siRNA (NC), 5.0 μM SIP-SII, or dual treatment with SIP-SII and Akt siRNA (si-Akt) for 24 h. Cell migration assay results for RT112 cells (B) and JMSU1 cells (C) treated with SIP-SII alone or in combination with si-Akt for 24 h. Representative images at 200x magnification. Data are mean ± SD (error bars) of three experiments performed in triplicate. **P < 0.01 vs. DMSO; n = 3. Western blot analyses of RT112 (D) and JMSU1 (E) cells treated with DMSO, SIP-SII, or the combination of SIP-SII and si-Akt for 24 h.