Research Paper Volume 11, Issue 18 pp 7830—7846

Downregulation of LncRNA-XIST inhibited development of non-small cell lung cancer by activating miR-335/SOD2/ROS signal pathway mediated pyroptotic cell death

Figure 7. The effects of LncRNA-XIST on A549 cell proliferation and apoptosis by targeting miR-335/SOD2 axis. (A, B) Colony formation assay and (C) CCK-8 assay were used to detect A549 cell proliferation. (D, E) The apoptosis ratio of A549 cells was quantified by FCM. (F, H) ROS levels in A549 cells were detected by DHE staining, which were quantified by (G, I) Image J software. (“NS” represented no statistical significance, “*” represented p < 0.05, “**” represented p < 0.01).