Figure 5. The downregulation of ACADS in HCC cells is associated with promoter hyper-methylation. (A) From the data obtained with the help of the UCSC Xena database, it can be seen that the normal liver tissues showed higher ACADS expression as compared to their HCC counterparts. It can also be noted that the DNA methylation levels were negatively correlated with ACADS expression in HCC tissues. (B) This figure shows the CpG islands of ACADS in the promoter sequence. (C) This figure shows that high DNA methylation levels of ACADS are associated with poor 2-, 5- and 10-year survival rates in HCC patients. (* P<0.05, **P<0.01).