Research Paper Volume 11, Issue 18 pp 7914—7937

TIP-B1 promotes kidney clear cell carcinoma growth and metastasis via EGFR/AKT signaling

Figure 1. Identify TIP-B1 is overexpressed in KIRC and predict aggressive clinicopathological traits. (A) Venn diagram of differentially expressed genes in GSE781, GSE15641and GSE73121datasets. (B) The TIP-B1 in KIRC tumor samples and pair-matched tissues. Each dot represents one sample. (C) TCGA cohort analysis of the TIP-B1 in KIRC tumor samples and pair-matched normal tissues. (DE) Overall survival (D) and disease-free survival (E) curve of KIRC patients with low and high TIP-B1 expression. (F) ROC curve of TIP-B1 between KIRC and normal tissues (G) TIP-B1 expression across 26 human tumor and paired tissues. (HM) Relative expression levels of TIP-B1 in TCGA-KIRC subgroup: pathological stage (H) tumor grade (I) recurrence status (J) tumor stage (K) lymphatic invasion (L) metastasis status (M). (N) ROC analysis to assess the specificity and sensitivity of TIP-B1 to differentiate between high and low group in KIRC tumor group. (O) Multivariate cox regression analyses of TIP-B1 expression with overall survival in TCGA database. The HR are presented as the means (95% confidence interval). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.