Research Paper Volume 11, Issue 18 pp 7914—7937

TIP-B1 promotes kidney clear cell carcinoma growth and metastasis via EGFR/AKT signaling

Figure 2. TIP-B1 is frequently upregulated in KIRC patients and correlates with poor prognosis. (A) RT-PCR analysis of TIP-B1 expression levels in 18 KIRC tissues and paired non-tumor kidney tissues. (B) Western blot analysis of TIP-B1 expression levels in 18 KIRC tissues and paired non-tumor kidney tissues. (C) Western blot analysis of TIP-B1expression levels in matched para-tumor, primary-tumor and recurrent tumor tissues from the same case. (D) Representative TMA images showing NR1B2 staining, and comparison of the IHC score between tumor and non-tumor kidney tissues. (E) Kaplan–Meier analysis of TMA patients with low versus high expression levels of TIP-B1. (FG) Kaplan-Meier survival curve of TIP-B1 high-expressing and low-expressing patients was compared in Fuhrman stages I−II (F) and Fuhrman stages III−IV (G) subgroups.