Research Paper Volume 11, Issue 18 pp 7914—7937

TIP-B1 promotes kidney clear cell carcinoma growth and metastasis via EGFR/AKT signaling

Figure 4. TIP-B1 knockdown inhibits KIRC tumor growth and metastasis. (A) Representative images of xenografts (arrows) were taken 5 weeks after injection. (B) The gross of tumors in sh-TIP-B1 and control groups. (CD) Analysis of tumor volume (C) and weight (D) of xenograft tumors. (E) Representative images of metastasis by an in vivo bioluminescence imaging system. (F) Macroscopic appearance of lung metastatic nodule(arrows). (G) HE images of pulmonary micrometastases. (H) the number of pulmonary metastasis were compared. (I) Weights of the lung were compared. (J) Mouse survival curves.