Research Paper Volume 11, Issue 20 pp 8845—8859

COL6A6 interacted with P4HA3 to suppress the growth and metastasis of pituitary adenoma via blocking PI3K-Akt pathway

Figure 5. Effect of COL6A6 on the PI3K-Akt signaling pathway through interacting with P4HA3. (A and B) Western blotting was used to detect the expression of COL6A6, P4HA3, PI3K-Akt pathway-related protein in AtT-20 and HP75 cells; (C and D) Coimmunoprecipitation to validate the COL6A6-P4HA3 interaction. **P<0.01, ***P<0.001, compared with NC group; ##P<0.01, compared with COL6A6 group.