Research Paper Volume 11, Issue 18 pp 7978—7995

GSK-3β and ERK1/2 incongruously act in tau hyperphosphorylation in SPS-induced PTSD rats

Figure 1. SPS induces PTSD-like anxiety in rats. (A) Time flow diagram of events in the experimental design. (B) Corticosterone was detected by ELISA kit. And the level of corticosterone was significantly increased in SPS-rats hippocampi. The data represent as mean ± SEM, n=3. (C) Rats’ weigh was measured on the first and seventh day, the data showed a lower weight gain in SPS exposed group. (D) The path diagrams of the elevated plus maze. (E and F) The percentage of open-arm entries and the percentage of time spent in open-arm were measured. SPS model showed significant reduction in the number of entries and time spent in the open-arm compared to control. (G) Anxiety index was calculated and the SPS group showed higher values. (H) The path diagrams representative of the open field test. (I) No significant difference in the time spent in the center. (J) The times of vertical exploration is significantly decreased in SPS model. (K) The total distance covered showed no changes compared with the control group. Behavior data show mean ± SEM, n=15, *P < 0.05, **P < 0.01 vs control.