Research Paper Volume 11, Issue 18 pp 7978—7995

GSK-3β and ERK1/2 incongruously act in tau hyperphosphorylation in SPS-induced PTSD rats

Figure 4. SPS downregulates the activity of AKT and SGK1 expression level. (A) WB results showed the level of AKT, p-AKT at Ser 473, SGK1. (B and C) The level of p-AKT was decreased, but total AKT protein level didn’t change. Protein (D) and mRNA (E) levels of SGK1 were markedly decreased in SPS rats compared to control. All data represent mean ± SEM, n=3, *P < 0.05 vs control.