Editorial Volume 11, Issue 18 pp 7331—7333

Adipogenic progenitors keep muscle stem cells young

Figure 1. Fibro-adipogenic progenitors (FAPs) dynamically cross-talk with the muscle stem cell (MuSC) niche to regulate regeneration and ECM/lipid turnover in different patho-physiologcal cues. (A) FAPs have distinct cellular fates and functions in different patho-physiological conditions; support to muscle fibers in homeostatic conditions [5]; support to muscle stem cells during regeneration [2]; pathological differentiation to fat and fibrosis [4,6]. (B) Aging alters the support of FAPs to MuSCs and regeneration and promotes their pathological skewing to fibrosis over adipogenesis [6].