Research Paper Volume 11, Issue 21 pp 9264—9279

Dopaminergic neuron injury in Parkinson’s disease is mitigated by interfering lncRNA SNHG14 expression to regulate the miR-133b/ α-synuclein pathway

Figure 1. SNHG14 expression was increased in PD mouse model. PD mouse models (n=7) were constructed, with the sham group (n=7) served as control. The motor function of PD mice was assessed with (A) rotarod performance, (B) reversed screen test, and (C) forelimb grip strength test. (D) Immunohistochemistry staining was performed to determine the number of Tyrosine Hydroxylase (TH)-positive DA neuron in the brain tissues of mice. (E) Relative expression of SNHG14 and miR-133b in brain tissues of mice was quantified by qRT-PCR. (F) Protein level of α-syn and SP-1 in brain tissues of mice was analyzed with western blotting. *P<0.05, **P<0.01 compared with sham group.