Research Paper Volume 11, Issue 21 pp 9264—9279

Dopaminergic neuron injury in Parkinson’s disease is mitigated by interfering lncRNA SNHG14 expression to regulate the miR-133b/ α-synuclein pathway

Figure 2. The binding between SP-1 and SNHG14 promoter was influenced by rotenone. Clonal mesencephalic DA cell line MN9D cells were treated with 1μmol/L rotenone. (A) SP-1 protein level in MN9D cells was determined by western blotting. (B) The binding activity of SP-1 to the promoter of SNHG14 was evaluated with chromatin immunoprecipitation (ChIP) assay. **P<0.01 compared with control.