Research Paper Volume 11, Issue 21 pp 9280—9294

Loss of FoxA2 accelerates neoplastic changes in the intrahepatic bile duct partly via the MAPK signaling pathway

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Figure 1. The correlation between intratumor FOXA2 expression and outcomes. (A) Representative immunostaining images of FOXA2 in ICC; (B) Protein level of FOXA2 in adjacent noncancerous tissue and tumor tissue. GAPDH was used as the loading control; (C) Paired analysis showed that FOXA2 expression was decreased in tumor samples. T: tumor tissue; N: adjacent normal tissue; (D) The overall survival (OS) and recurrence-free survival (RFS) rates of 85 ICC patients were compared between the low- and high-FOXA2 expression groups (P < 0.001, log-rank test).