Research Paper Volume 11, Issue 21 pp 9280—9294

Loss of FoxA2 accelerates neoplastic changes in the intrahepatic bile duct partly via the MAPK signaling pathway

Figure 1. The correlation between intratumor FOXA2 expression and outcomes. (A) Representative immunostaining images of FOXA2 in ICC; (B) Protein level of FOXA2 in adjacent noncancerous tissue and tumor tissue. GAPDH was used as the loading control; (C) Paired analysis showed that FOXA2 expression was decreased in tumor samples. T: tumor tissue; N: adjacent normal tissue; (D) The overall survival (OS) and recurrence-free survival (RFS) rates of 85 ICC patients were compared between the low- and high-FOXA2 expression groups (P < 0.001, log-rank test).