Research Paper Volume 11, Issue 21 pp 9280—9294

Loss of FoxA2 accelerates neoplastic changes in the intrahepatic bile duct partly via the MAPK signaling pathway

Figure 4. The key components of the MAPK signaling pathway were activated in FoxA2-/- mice. (A, B) IHC and Western blotting analysis of low FoxA2 and high p-ERK1/2, CREB1 and RAS expression in FoxA2-/- mice; © The heatmap shows the activation of key genes in the MAPK signaling pathway in ICC patients. These genes were selected from the KEGG database for MAPK signaling pathways (Supplementary Table 1); (D) The correlation plot shows that low FOXA2 expression was correlated with high expression of genes in the MAPK signaling pathway in ICC patients.