Research Paper Volume 11, Issue 21 pp 9280—9294

Loss of FoxA2 accelerates neoplastic changes in the intrahepatic bile duct partly via the MAPK signaling pathway

Figure 5. The suppression of FoxA2 promotes activation of the MAPK signaling pathway. (A) The effect of FOXA2 suppression in HuCCT1 cells by siFOXA2; (B) Cell proliferation was detected with EdU in ICC cells after suppression of FoxA2; (C) The invasion assay was used to assess the effects of FoxA2 down regulation on ICC cell invasion; (D) The expression of ERK1, P-ERK1/2, CREB1 and RAS in ICC cell lines was detected by Western blot after the suppression of FoxA2.