Editorial Volume 11, Issue 20 pp 8730—8732

Embrace the fat when getting old

Figure 1. Lipid-Associated Macrophage (LAM) cells expressing Trem2 surround adipocytes in “crown-like structures” thereby preventing leakage of potentially harmful substances to the periphery with systemic consequences. Aging and/or obesity may eventually lead to a loss of LAM cells and thus bursting of hypertrophic adipocytes. Metabolic derailments could putatively be counteracted by activation of Trem2 or pharmacological inhibition of Trem1.