Research Paper Volume 11, Issue 20 pp 8937—8950

Beneficial effects of PGC-1α in the substantia nigra of a mouse model of MPTP-induced dopaminergic neurotoxicity

Figure 1. Distribution of lentivirus in the SN, striatum region and the representative schematic. (A) shows immunohistochemical staining of the substantia nigra in the control group. (A1 and A2) show successful LV-PGC-1α infection in the substantia nigra of mice. (B1 and B2) show successful LV-PGC-1α-siRNA infection of the substantia nigra of mice. (C1 and C2) show the striatum infected with LV-PGC-1α and LV-PGC-1α-siRNA, respectively. (D) shows a schematic representation of the experimental paradigm. Scale bar: 20 μm. Magnification: ×200 for A1, B1; ×400 for A, A2, B2, C1, C2.