Research Paper Volume 11, Issue 20 pp 8937—8950

Beneficial effects of PGC-1α in the substantia nigra of a mouse model of MPTP-induced dopaminergic neurotoxicity

Figure 2. Expression of PGC-1α in the SN of C57BL mice. (A, B) PGC-1α protein expression patterns; (C, D) PGC-1α protein expression patterns after overexpression, detected using western blotting and real-time PCR; (E, F) PGC-1 α protein expression after knockdown, detected using western blotting and real-time PCR; Quantification of the results of three experiments are presented as the means ± SD. The groups were con (con group), M (MPTP group), LVcon+M (solvent of lentivirus+MPTP group), LV+M (lentivirus+MPTP group), LVPGC+M (LV-PGC-1α+MPTP group), LVsiRNA+M (LV-PGC-1αsiRNA+MPTP group); #P<0.05, ##P<0.01 compared with the LV+M group, **P<0.01, *P<0.05 compared with the con group.