Research Paper Volume 11, Issue 20 pp 8937—8950

Beneficial effects of PGC-1α in the substantia nigra of a mouse model of MPTP-induced dopaminergic neurotoxicity

Figure 3. Mouse behavioral changes before and after MPTP administration. (A, B) The overall performance of mice in the rotarod test one day before injection and three days and six days after injection. The results of the three experiments are quantified as the means ± SD. The groups were con (con group), M (MPTP group), LVcon+M (solvent of lentivirus+MPTP group), LV+M (lentivirus+MPTP group), LVPGC+M (LV-PGC-1α+MPTP group), and LVsiRNA+M (LV-PGC-1αsiRNA+MPTP group);*P<0.01, #P<0.05 compared with before injection; ☆P<0.01 compared with the con group; **P<0.01 compared with the LV+M group.