Research Paper Volume 11, Issue 20 pp 8937—8950

Beneficial effects of PGC-1α in the substantia nigra of a mouse model of MPTP-induced dopaminergic neurotoxicity

Figure 4. Expression of TH and TH immunopositive cells in the substantia nigra of C57BL mice. (AD) TH protein expression detected using western blotting; (EG) TH immunopositive cells (scale bar, 20 μm. magnification, ×400). Quantification of the results from the three experiments are represented as the means ± SD. The groups were con (con group), M (MPTP group), LVcon+M (solvent of lentivirus+MPTP group), LV+M (lentivirus+MPTP group), LVPGC+M (LV-PGC-1α+MPTP group), LVsiRNA+M (LV-PGC-1αsiRNA+MPTP group);*P<0.05, ##P<0.01, ###P<0.001, compared with the LV+M group; #P<0.05, ***P<0.001, **P<0.01 compared with the con group.