Research Paper Volume 11, Issue 20 pp 8937—8950

Beneficial effects of PGC-1α in the substantia nigra of a mouse model of MPTP-induced dopaminergic neurotoxicity

Figure 6. Effects of PGC-1α on the level of superoxide dismutase in a mouse model of Parkinson’s disease (PD) induced by MPTP. (A, B) Activity of SOD in the SN region of C57BL/6 mice with PGC-1α overexpression or knockdown. Quantification of the results of the three experiments are presented as the means ± SD. The groups were con (con group), M (MPTP group), LVcon+M (solvent of lentivirus+MPTP group), LV+M (lentivirus+MPTP group), LVPGC+M (LV-PGC-1α+MPTP group), and LVsiRNA+M (LV-PGC-1αsiRNA+MPTP group);*P<0.01, **P<0.05 compared with the LV+M group; #P<0.01, ##P<0.05 compared with the con group.