Baicalein attenuates OVA-induced allergic airway inflammation through the inhibition of the NF-κB signaling pathway

Tingting Xu; Xiangting Ge; Chun Lu; Wei Dai; Hongjin Chen; Zhongxiang Xiao; Liqin Wu; Guang Liang; Songmin Ying; Yali Zhang; Yuanrong Dai

doi:doi:10.18632/aging.102371

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Research Paper Volume 11, Issue 21 pp 9310—9327

Baicalein attenuates OVA-induced allergic airway inflammation through the inhibition of the NF-κB signaling pathway

Figure 2. Baicalein reduces OVA-induced Th2 inflammation. The OVA/Al(OH)₃ model is characterized by Th2-driven airway inflammation. To determine the effect of Baicalein on Th2 airway inflammation, ELISA was performed to detect the levels of IgE in serum (A) and IL-4, IL-5, and IL-13 in BALF (B–D) and lung homogenate (E–G) (results are presented as the mean ± SEM. n = 6 mice per group; ^##P < 0.01 compared with the control group; *P < 0.05, **P < 0.01 compared with the OVA/Vehicle group).