Research Paper Volume 11, Issue 20 pp 9090—9110

Long noncoding RNA ARHGAP27P1 inhibits gastric cancer cell proliferation and cell cycle progression through epigenetically regulating p15 and p16

Figure 1. Upregulation of ARHGAP27P1 predicted advanced disease and poorer OS of GC. (A) The ARHGAP27P1 levels in GC tissues and adjacent noncancerous tissues were detected by RT-qPCR (n=112). (B) The fold change of ARHGAP27P1 expression in GC tissues compared with that in the paired noncancerous tissues for each patient. (C) The correlation between ARHGAP27P1 expression and TNM stage, invasion depth and lymphatic metastasis. (D) Kaplan-Meier analysis of OS according to ARHGAP27P1 expression levels. (E) The expression levels of plasma ARHGAP27P1 in GC patients (n=53) and healthy controls (n=53) were detected by RT-qPCR. (F) The correlation between plasma ARHGAP27P1 expression and TNM stage, invasion depth and lymphatic metastasis. (G) The ROC curve of plasma ARHGAP27P1 for diagnosis of GC. *P < 0.05, **P < 0.01, ***P < 0.001.