Research Paper Volume 11, Issue 20 pp 9090—9110

Long noncoding RNA ARHGAP27P1 inhibits gastric cancer cell proliferation and cell cycle progression through epigenetically regulating p15 and p16

Figure 6. Silencing of JMJD3, p15 or p16 reversed the suppressive effect of ARHGAP27P1 in GC malignant progression. (A) ARHGAP27P1-overexpressing SGC-7901 and AGS cells were cotransfected with si-JMJD3, si-p15 or si-p16. Cell proliferation was determined by cell counting assays. (B) Colony formation assays. (C) Cell cycle assays and cell apoptosis assays. (D) Transwell migration and invasion assays. *P < 0.05 versus vector. #P < 0.05, ##P < 0.01 versus ARHGAP27P1.