Figure 6. Silencing of JMJD3, p15 or p16 reversed the suppressive effect of ARHGAP27P1 in GC malignant progression. (A) ARHGAP27P1-overexpressing SGC-7901 and AGS cells were cotransfected with si-JMJD3, si-p15 or si-p16. Cell proliferation was determined by cell counting assays. (B) Colony formation assays. (C) Cell cycle assays and cell apoptosis assays. (D) Transwell migration and invasion assays. *P < 0.05 versus vector. #P < 0.05, ##P < 0.01 versus ARHGAP27P1.