Research Paper Volume 11, Issue 20 pp 9090—9110

Long noncoding RNA ARHGAP27P1 inhibits gastric cancer cell proliferation and cell cycle progression through epigenetically regulating p15 and p16

Figure 7. Overexpression of ARHGAP27P1 inhibited tumor growth in vivo. (A) Growth curves of tumors from vector or ARHGAP27P1 groups were shown. Tumor volumes were calculated every 3 days. (B) Tumor samples and tumor weights from respective groups were represented. (C) RT-qPCR analysis of ARHGAP27P1, JMJD3, p15, p16 and p57 in xenograft tumors. (D) Histopathology and immunostainings of JMJD3, p15, p16 and Ki-67 in paraffin tumor sections. (E) Representative blots of JMJD3, EZH2, SUZ12, H3K4me3, H3K27me3, p15, p16, and p57 in tumor tissues. *P < 0.05, **P < 0.01 versus vector.