Research Paper Volume 11, Issue 20 pp 9147—9166

Dysfunctional interactions between the default mode network and the dorsal attention network in subtypes of amnestic mild cognitive impairment

Figure 4. Altered anticorrelations between the DMN and DAN among the four groups. (A) Regions showing altered anticorrelations with the left PCC seed among the four groups; (B) Regions showing altered anticorrelations with the left FEF seed between the aMCI-s and AD groups; (C) Regions showing altered anticorrelations with the left mPFC seed between the aMCI-m and NC groups; (D) Regions showing altered anticorrelations with the left IPS seed between the aMCI-m and AD groups. Significant regions (shown in warm yellows) were overlaid on the main effect maps (shown in blue) which were corrected using a voxel threshold of FWE correction (P < 0.05). Bar graphs displayed mean rsFC z scores for the AD, aMCI-s, aMCI-m and NC groups and the error bars represented standard deviation. Mean rsFC z scores were analyzed with SPSS 20 using one-way ANOVA. *p < 0.05. **p < 0.01. Abbreviations: DMN: default mode network; DAN: dorsal attention network; PCC: posterior cingulate cortex; IPS: intraparietal sulcus; FEF: frontal eye fields; mPFC: medial prefrontal cortex; SOG: superior occipital gyrus; AD: Alzheimer's disease; aMCI-s: single-domain of amnestic mild cognitive impairment; aMCI-m: multiple-domain of amnestic mild cognitive impairment; NC: normal controls.