Research Paper Volume 11, Issue 20 pp 9167—9187

Bone marrow-derived mesenchymal stem cells in three-dimensional co-culture attenuate degeneration of nucleus pulposus cells

Figure 7. A schematic diagram of the proposed mechanisms of BMSCs’ protection of senescent NP cells during coculture. ZMPSTE24 was upregulated to reduce MMP9 to restore NP cells’ functional ECM balance. TGFβ and RelA which were involved in senescent pathway were alleviated during NP cells degeneration.