Research Paper Volume 11, Issue 20 pp 9209—9219

Overexpression of steroid sulfotransferase genes is associated with worsened prognosis and with immune exclusion in clear cell-renal cell carcinoma

Figure 2. Functional enrichment of steroid SULT gene-altered ccRCC. Reproduced from the TCGA KIRC dataset with cBioPortal platform, shown are (A) Pattern and significances of enrichment of significantly mutated genes and frequent copy number variances indicated by hallmark genes between cases with upregulated or unchanged steroid SULT gene. (B) Correlation of expression level between steroid SULT genes and VHL, SETD2, PBRM1, KDM6A, KDM5C, MLL2 and CDKN2A. (CD) functional analysis of enriched genes at mRNA (RNA seq) and protein levels (RPPA) generated at cBioPortal (volcano plots on left) and processed at NET-GE platform (bar plots on right) and (E) Select enriched gene sets were validated using the GSEA enrichment analyses.