Research Paper Volume 11, Issue 21 pp 9405—9423

Systematic identification of lncRNA-based prognostic biomarkers for glioblastoma

Figure 4. (A) GBM patients were classified into three clusters (C1-C3) which represent the underlying GBM subtypes by integrating multi-omics data using the iCluster. Differentially expressed lncRNAs and mRNAs in the GBM patients and the subtypes were identified. (BC) Analysis of network topology for various soft-thresholding powers. (D) WGCNA analysis was then performed to identify co-expression lncRNA modules (M1−M23) using GBM transcriptome which contain GBM-related lncRNAs and mRNAs followed by functional enrichment analysis of the different modules. (E) The relative multiple histogram of lncRNA ratio and PCG ratio in 23 modules, the p value is on the right, the horizontal axis represents the multiple of lncRNA ratio and PCG ratio in the module, and the vertical axis represents the modules.