Neuroprotective effects of protocatechuic aldehyde through PLK2/p-GSK3β/Nrf2 signaling pathway in both <i>in vivo</i> and <i>in vitro</i> models of Parkinson's disease

Chao Guo; Junrong Zhu; Jingwen Wang; Jialin Duan; Shanbo Ma; Ying Yin; Wei Quan; Wei Zhang; Yue Guan; Yi Ding; Aidong Wen; Yingdong Zhang

doi:doi:10.18632/aging.102394

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Research Paper Volume 11, Issue 21 pp 9424—9441

Neuroprotective effects of protocatechuic aldehyde through PLK2/p-GSK3β/Nrf2 signaling pathway in both in vivo and in vitro models of Parkinson's disease

Figure 12. GSK3β and Nrf2 were involved in PCA-induced protection. (A) The bands of GSK3β and nucleus Nrf2 after transfected with pcDNA3.1-GSK3β expression vector. (B) Quantification of nucleus Nrf2 levels after transfected with pcDNA3.1-GSK3β vector. (C) Analysis of cell viability in each group. (D–E) The expression of nucleus Nrf2 and cell viability after transfected with siRNA-Nrf2 and pcDNA3.1-Nrf2 vector. Data were presented as mean ± S.D., n = 6; ^*P < 0.05 vs. control group; ^#P< 0.05 vs. MPP⁺group; ^&P < 0.05 vs. si-Non group; ^△P < 0.05 vs. pc-Con group.