Research Paper Volume 11, Issue 21 pp 9424—9441

Neuroprotective effects of protocatechuic aldehyde through PLK2/p-GSK3β/Nrf2 signaling pathway in both in vivo and in vitro models of Parkinson's disease

Figure 12. GSK3β and Nrf2 were involved in PCA-induced protection. (A) The bands of GSK3β and nucleus Nrf2 after transfected with pcDNA3.1-GSK3β expression vector. (B) Quantification of nucleus Nrf2 levels after transfected with pcDNA3.1-GSK3β vector. (C) Analysis of cell viability in each group. (DE) The expression of nucleus Nrf2 and cell viability after transfected with siRNA-Nrf2 and pcDNA3.1-Nrf2 vector. Data were presented as mean ± S.D., n = 6; *P < 0.05 vs. control group; #P< 0.05 vs. MPP+group; &P < 0.05 vs. si-Non group; P < 0.05 vs. pc-Con group.