Research Paper Volume 11, Issue 21 pp 9424—9441

Neuroprotective effects of protocatechuic aldehyde through PLK2/p-GSK3β/Nrf2 signaling pathway in both in vivo and in vitro models of Parkinson's disease

Figure 2. PCA alleviated dopaminergic neuronal loss in MPTP-intoxicated mice. (A) The levels of dopamine, DOPAC and HVA in the striatum were measured by HPLC. (BC) Brain sections were immunostained for TH immunoreactivity in SN and TH positive cells were quantified. Scale bar, 50 μm. (D) Representative western blot bands and quantification of TH in each group. Data were expressed as mean ± S.D., n = 6; **P< 0.01,*P< 0.05 vs. control group; #P< 0.05 vs. MPTP group.