Research Paper Volume 11, Issue 21 pp 9442—9460

Long noncoding RNA DNM3OS promotes prostate stromal cells transformation via the miR-29a/29b/COL3A1 and miR-361/TGFβ1 axes

Figure 1. Selection of lncRNAs associated with benign prostatic hyperplasia (BPH) stroma and highly-expressed in prostate stromal tissues (A) Three microarray profiles reported differentially-expressed lncRNAs in prostate stromal tissues compared to prostatic epithelium (GSE9196, GSE3998, and GSE97284). The expression of lncRNA DNM3OS in (B) epithelial and stroma tissues according to GSE9196; (C) benign epithelium, prostatic intraepithelial neoplasia, tumors, stroma adjacent to benign epithelium, stroma adjacent to prostatic intraepithelial neoplasia, and stromal adjacent to tumor according to GSE97284; and (D) luminal cells, basal cells, stromal cells, and endothelial cells. (E) Differentially- expressed genes in the benign stromal cell line HPS-19I upon TGFβ treatment according to GSE51624. (F) Differentially- expressed genes in primary prostate stromal cells (PrSCs) upon TGFβ treatment. *P<0.05, **P<0.01.