Research Paper Volume 11, Issue 21 pp 9492—9499

Ser-Tyr and Asn-Ala, vasorelaxing dipeptides found by comprehensive screening, reduce blood pressure via different age-dependent mechanisms

Figure 5. NA exhibits vasorelaxing and anti-hypertensive effects by activating the CCK system in SHR in the advanced stage. Effects of different inhibitors of vasorelaxing activity of NA (A). The dose dependency of the vasorelaxing activity of NA (B). NA-induced anti-hypertensive effects were blocked by lorglumide, an antagonist for the CCK receptor (C). Values are expressed as the means ± SEM (A, n = 3-4; B, n = 5-8; C, n=4-7). *P < 0.05, compared with the NA group (A). *P < 0.05, compared with the control group. #P< 0.05 compared with the NA + lorglumide group (C).