Figure 6. Atorvastatin inhibits ESCC growth in vivo. (A) The photograph shows tumors from PDX mice treated with vehicle or atorvastatin (5 mg/kg or 20mg/kg). (B) Tumor volume in each of the treatment groups was measured weekly, (C) with tumor weight measured at day 28. The asterisk (* P < 0.05) indicates a significant decrease in tumor volume from atorvastatin-treated mice. (D) The expression of ERKT185/Y187, CDK1T14 and BRCA1S1189 was examined by IHC (400×). Data are expressed as positive cell values ± SD. The asterisks (* P < 0.05, ** P < 0.01) indicate a significant decrease in ERKT185/Y187, CDK1T14 and BRCA1S1189 in atorvastatin-treated tissues compared to vehicle group.