Research Paper Volume 11, Issue 21 pp 9556—9568

Dexmedetomidine inhibits neuronal apoptosis by inducing Sigma-1 receptor signaling in cerebral ischemia-reperfusion injury

Figure 2. Dexmedetomidine attenuated the neuronal apoptosis induced by CIRI. (A) TUNEL staining was performed on slices from the cerebral ischemic penumbra. a. Sham operation (Sham) group, b. dexmedetomidine administration (Dex) group, c. MCAO model control (MCAO) group, d. MCAO + dexmedetomidine administration (MCAO + Dex) group. (B) Ratio of positive cells. Magnification is 400x. n = 6. Data are expressed as the mean ± SEM. *P < 0.05, **P < 0.01 compared with the sham group; #P < 0.05, ##P < 0.01 compared with the MCAO group.