Figure 2. Dexmedetomidine attenuated the neuronal apoptosis induced by CIRI. (A) TUNEL staining was performed on slices from the cerebral ischemic penumbra. a. Sham operation (Sham) group, b. dexmedetomidine administration (Dex) group, c. MCAO model control (MCAO) group, d. MCAO + dexmedetomidine administration (MCAO + Dex) group. (B) Ratio of positive cells. Magnification is 400x. n = 6. Data are expressed as the mean ± SEM. *P < 0.05, **P < 0.01 compared with the sham group; #P < 0.05, ##P < 0.01 compared with the MCAO group.