Research Paper Volume 11, Issue 21 pp 9643—9660

Oncogenic USP22 supports gastric cancer growth and metastasis by activating c-Myc/NAMPT/SIRT1-dependent FOXO1 and YAP signaling

Figure 4. USP22 silencing suppresses in vitro GC cell migration and invasion. (AB) Transwell assay results show total number of (A) migratory and (B) invasive BGC-823 and HGC-27 cells that are untransfected (Mock) or transfected with 100 nM siNC or siUSP22-1 at 48 h after transfection. Note: Magnification: 200×; Data are expressed as mean ± SD of three replicates. *p < 0.05 compared with mock or siNC group.