Review Volume 11, Issue 21 pp 9932β€”9946

Emerging roles of piRNAs in cancer: challenges and prospects

Figure 1. piRNA biosynthesis mechanism. piRNA intermediates form a complex with piwi, then the complex is cleavage by Zuc or Papi-dependent trimmer to form 3’end. After the complex methylation in cytoplasm, the mature piRNA-piwi complex is producted. Abbreviations: Zuc: zucchini.