Review Volume 11, Issue 21 pp 9932—9946

Emerging roles of piRNAs in cancer: challenges and prospects

Figure 2. ping-pong mechanism. primary piRNAs bind to AGO3 or AUB proteins to form piRNA/Ago3 or piRNA/AUB complexes, generate new piRNAs using piRNA and piRNA/Ago3 or piRNA/AUB complexes as templates, using new generated piRNA to synthesis another piRNA in same method.