Research Paper Volume 11, Issue 21 pp 9738—9766

Selected by gene co-expression network and molecular docking analyses, ENMD-2076 is highly effective in glioblastoma-bearing rats

Figure 6. (AB) ENMD-2076 suppressing the invasion ability of LN18, T98G cells in the Transwell assay. 5 random fields were counted for each condition. (C) Protein levels of E-cadherin, Vimentin, Cytokeratin and MMP-9 evaluated by immunofluorescence demonstrated ENMD-2076 inhibit glioblastoma invasion by suppressing EMT. (DF) Flow cytometry results showed that ENMD-2076 induced glioblastoma cells (LN18, T98G) apoptosis. ENMD-2076 showed pro-apoptotic effects on LN18, T98G cells.