Research Paper Volume 11, Issue 21 pp 9778—9793

Ubiquitin specific peptidase 5 promotes ovarian cancer cell proliferation through deubiquitinating HDAC2

Figure 1. Genomic amplification of USP5 in ovarian cancer was correlated with overall survival of patients. (A) CNV analysis of USP family genes in TCGA cohort (n=579). (B) Kaplan-Meier survival analysis between patients with and without USP15 amplification using TCGA cohort (n=564). (C) USP15 mRNA levels were higher in samples with USP5 amplification than in those without USP5 amplification. (D) USP5 copy number alteration in patients of cohort 1 by real-time PCR analysis (n=80). The cut-off for amplification was set at 4 copies per tumor cell. (E) Kaplan-Meier survival analysis between patients with and without USP15 amplification using cohort 1 (n=80).