Research Paper Volume 11, Issue 21 pp 9778—9793

Ubiquitin specific peptidase 5 promotes ovarian cancer cell proliferation through deubiquitinating HDAC2

Figure 2. USP5 was up-regulated in ovarian cancer tissues and associated with overall survival. (A) Immunohistochemistry staining of USP5 in ovarian cancer and noncancerous tissues from cohort 2. Scale bar: 100 μm. The patients were divided into two groups USP5 low expression and USP5 high expression with a cut-off of 25% of positively-stained cancer cells. (B) Analysis of correlation between USP5 expression, FIGO stage and tumor size in cohort 2. (C) Kaplan-Meier survival analysis of ovarian cancer patients with high expression of USP5 and low expression of USP5 (log-rank analysis). (D) Multivariate regression analysis in cohort 2.