Research Paper Volume 11, Issue 21 pp 9846—9861

Iron overload resulting from the chronic oral administration of ferric citrate induces parkinsonism phenotypes in middle-aged mice

Figure 2. Motor and cognitive defects are associated with iron accumulation in ferric citrate-supplemented mice. (A) Representative maps of mouse activities in the open field test. (B) Effect of ferric citrate on the distance traveled by mice. (C) Effect of ferric citrate on the speed of mice. (D) Effect of ferric citrate on the time mice spent in the center zone. (E) Effect of ferric citrate on the frequency mice moved into the center zone. (F) Effect of ferric citrate on the distance mice traveled in the center zone. (G) Effect of ferric citrate on the fall latency of mice. (H and I) Effect of ferric citrate on the performance of mice in the pole test. (J) Effect of ferric citrate on the time to fall of mice in the traction test. (K) Effect of ferric citrate on the cognitive functions of mice, as evidenced by the quantification of their frequency to enter the novel arm in the Y-maze test. Error bars indicate SD. Compared with the Ctr group, *p<0.05 and **p<0.01. Compared with the 1.25% ferric citrate group #p<0.05 and ##p<0.01.