Research Paper Volume 11, Issue 21 pp 9875—9892

Promising therapeutic effect of thapsigargin nanoparticles on chronic kidney disease through the activation of Nrf2 and FoxO1

Figure 7. TG NPs and KIM-1-TG NPs protect against tubulointerstitial injury in mice with CKD induced by adenine. (A) Representative photographs of histological changes showing sections of renal tissue from mice after H&E staining. Immunohistochemical analysis of the protein expression of LC3 (B), FoxO1 (C) and Nrf2 (D) in the sections of renal tissue. The percentage of LC3-positive cells was determined using HistoQuest software (TissueGnostics). (A, B) Scale bar = 50 μm. (C, D) Scale bar = 25 μm.