Figure 7. TG NPs and KIM-1-TG NPs protect against tubulointerstitial injury in mice with CKD induced by adenine. (A) Representative photographs of histological changes showing sections of renal tissue from mice after H&E staining. Immunohistochemical analysis of the protein expression of LC3 (B), FoxO1 (C) and Nrf2 (D) in the sections of renal tissue. The percentage of LC3-positive cells was determined using HistoQuest software (TissueGnostics). (A, B) Scale bar = 50 μm. (C, D) Scale bar = 25 μm.